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Cayenne (Capsicum frutescens L.) contains capsaicin, substance that puts the heat or pungency in chilies. Capsaicin is used to relieve pain. Capsaicin is available as a cream, ointment, liniment, and, patch but those dosage forms are oily. In this study the gel formulation (has no oil content) was chosen containing varying cayenne extract (1.5%, 2%, 2.5%) and carbomer 940 as gelling agent. The evaluation included stability, organoleptic, pH, homogeneity, viscosity, consistency, spreading test, and acceptability (hedonic test). The result showed that all formula were not stable after 7 days and the most acceptance formula was formula A with 1.5% cayenne extract.
Key words: cayenne (Capsicum frutescens L.), capsaicin, gel, carbomer 940
